In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues

Naresh Podila; Mithun Rudrapal; Subramanyam Sibbala; Atul R. Bendale; Yanadaiah Palakurthi; Molakpogu Ravindra Babu; Kiran Manda; Renzon Daniel Cosme Pecho; Sreelatha Muddisetti

doi:10.3897/pharmacia.70.e109898

In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues

Naresh Podila
, Mithun Rudrapal
, Subramanyam Sibbala
, Atul R. Bendale
, Yanadaiah Palakurthi
, Molakpogu Ravindra Babu
, Kiran Manda
, Renzon Daniel Cosme Pecho
, Sreelatha Muddisetti

Vignan's Foundation for Science, Technology & Research
Lovely Professional University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo- benzothiazole analogues in inhibiting the proliferation of cancer cells either by promoting microtubule formation or affecting microtubules, thereby preventing microtubule breakdown.

Original language	English
Pages (from-to)	887-894
Number of pages	8
Journal	Pharmacia
Volume	70
Issue number	4
DOIs	https://doi.org/10.3897/pharmacia.70.e109898
State	Published - 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

1,2,4-triazole
Benzothiazole
antimitotic activity
aspirin
cancer
mung beans

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10.3897/pharmacia.70.e109898

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title = "In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues",

abstract = "In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo- benzothiazole analogues in inhibiting the proliferation of cancer cells either by promoting microtubule formation or affecting microtubules, thereby preventing microtubule breakdown.",

keywords = "1,2,4-triazole, Benzothiazole, antimitotic activity, aspirin, cancer, mung beans",

author = "Naresh Podila and Mithun Rudrapal and Subramanyam Sibbala and Bendale, \{Atul R.\} and Yanadaiah Palakurthi and Babu, \{Molakpogu Ravindra\} and Kiran Manda and Pecho, \{Renzon Daniel Cosme\} and Sreelatha Muddisetti",

note = "Publisher Copyright: {\textcopyright} Podila N et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2023",

doi = "10.3897/pharmacia.70.e109898",

language = "English",

volume = "70",

pages = "887--894",

journal = "Pharmacia",

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TY - JOUR

T1 - In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues

AU - Podila, Naresh

AU - Rudrapal, Mithun

AU - Sibbala, Subramanyam

AU - Bendale, Atul R.

AU - Palakurthi, Yanadaiah

AU - Babu, Molakpogu Ravindra

AU - Manda, Kiran

AU - Pecho, Renzon Daniel Cosme

AU - Muddisetti, Sreelatha

N1 - Publisher Copyright: © Podila N et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2023

Y1 - 2023

N2 - In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo- benzothiazole analogues in inhibiting the proliferation of cancer cells either by promoting microtubule formation or affecting microtubules, thereby preventing microtubule breakdown.

AB - In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo- benzothiazole analogues in inhibiting the proliferation of cancer cells either by promoting microtubule formation or affecting microtubules, thereby preventing microtubule breakdown.

KW - 1,2,4-triazole

KW - Benzothiazole

KW - antimitotic activity

KW - aspirin

KW - cancer

KW - mung beans

UR - https://www.scopus.com/pages/publications/85173676502

U2 - 10.3897/pharmacia.70.e109898

DO - 10.3897/pharmacia.70.e109898

M3 - Article

AN - SCOPUS:85173676502

SN - 0428-0296

VL - 70

SP - 887

EP - 894

JO - Pharmacia

JF - Pharmacia

IS - 4

ER -

In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues

Abstract

UN SDGs

Keywords

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