SARS-COV-2 y su efecto a nivel de tejido renal: Una revisión narrativa

Aldo Flores Gavino; Ricardo Espinoza Anchaygua; Percy Herrera-Añazco; Alfonso J. Rodriguez-Morales

doi:10.35663/amp.2021.381.1885

SARS^-COV^-2 y su efecto a nivel de tejido renal: Una revisión narrativa

Translated title of the contribution: Effect of SARS^-COV^-2 on kidney tissue: A narrative review

Aldo Flores Gavino
, Ricardo Espinoza Anchaygua
, Percy Herrera-Añazco
, Alfonso J. Rodriguez-Morales

Universidad Peruana de Ciencias Aplicadas
Universidad Tecnológica de Pereira
Fundación Universitaria Autónoma de las Américas

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin-Angiotensin-Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.

Translated title of the contribution	Effect of SARS^-COV^-2 on kidney tissue: A narrative review
Original language	Spanish
Pages (from-to)	53-57
Number of pages	5
Journal	Acta Medica Peruana
Volume	38
Issue number	1
DOIs	https://doi.org/10.35663/amp.2021.381.1885
State	Published - 23 May 2021
Externally published	Yes

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title = "SARS-COV-2 y su efecto a nivel de tejido renal: Una revisi{\'o}n narrativa",

abstract = "We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin-Angiotensin-Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.",

keywords = "Acute kidney injury, COVID-19, Histopathology, Kidney, Pathophysiology, SARS-CoV-2",

author = "Gavino, \{Aldo Flores\} and Anchaygua, \{Ricardo Espinoza\} and Percy Herrera-A{\~n}azco and Rodriguez-Morales, \{Alfonso J.\}",

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AU - Gavino, Aldo Flores

AU - Anchaygua, Ricardo Espinoza

AU - Herrera-Añazco, Percy

AU - Rodriguez-Morales, Alfonso J.

PY - 2021/5/23

Y1 - 2021/5/23

N2 - We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin-Angiotensin-Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.

AB - We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin-Angiotensin-Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.

KW - Acute kidney injury

KW - COVID-19

KW - Histopathology

KW - Kidney

KW - Pathophysiology

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85182304909

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DO - 10.35663/amp.2021.381.1885

M3 - Artículo de revisión

AN - SCOPUS:85182304909

SN - 1018-8800

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SP - 53

EP - 57

JO - Acta Medica Peruana

JF - Acta Medica Peruana

IS - 1

ER -

SARS^-COV^-2 y su efecto a nivel de tejido renal: Una revisión narrativa

Abstract

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