Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

Sol Rodriguez; Fernando G. Torres; Karen N. Gonzales; Omar P. Troncoso; Marta Fernández-García; Daniel López

doi:10.1080/00914037.2020.1716225

Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

Sol Rodriguez, Fernando G. Torres, Karen N. Gonzales, Omar P. Troncoso, Marta Fernández-García, Daniel López

Pontificia Universidad Católica del Perú

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween^{^®} 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.

Original language	English
Pages (from-to)	338-344
Number of pages	7
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	70
Issue number	5
DOIs	https://doi.org/10.1080/00914037.2020.1716225
State	Published - 2021
Externally published	Yes

Keywords

Carrageenan
drug delivery
enrofloxacin
microgels

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10.1080/00914037.2020.1716225

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title = "Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique",

abstract = "κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween{\textregistered} 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.",

keywords = "Carrageenan, drug delivery, enrofloxacin, microgels",

author = "Sol Rodriguez and Torres, {Fernando G.} and Gonzales, {Karen N.} and Troncoso, {Omar P.} and Marta Fern{\'a}ndez-Garc{\'i}a and Daniel L{\'o}pez",

note = "Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2021",

doi = "10.1080/00914037.2020.1716225",

language = "English",

volume = "70",

pages = "338--344",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

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T1 - Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

AU - Rodriguez, Sol

AU - Torres, Fernando G.

AU - Gonzales, Karen N.

AU - Troncoso, Omar P.

AU - Fernández-García, Marta

AU - López, Daniel

PY - 2021

Y1 - 2021

N2 - κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween® 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.

AB - κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween® 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.

KW - Carrageenan

KW - drug delivery

KW - enrofloxacin

KW - microgels

UR - http://www.scopus.com/inward/record.url?scp=85078495989&partnerID=8YFLogxK

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DO - 10.1080/00914037.2020.1716225

M3 - Article

AN - SCOPUS:85078495989

SN - 0091-4037

VL - 70

SP - 338

EP - 344

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 5

ER -

Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

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Keywords

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