Global Overview of Von Willebrand Disease Research: A Bibliometric Study

INTRODUCTION: Von Willebrand disease (VWD) is a hereditary bleeding disorder with a high global prevalence. The aim of this study is to analyze the global landscape of scientific production on VWD. MATERIALS AND METHODS: A bibliometric study was conducted considering publications indexed in Scopus between 2020 and 2024. The search was performed in July 2025, identifying 951 documents, of which 588 original articles were included in the study. Productivity, impact, and co-authorship network indicators were evaluated using SciVal, Bibliometrix, and VOSviewer. RESULTS: The United States and the Netherlands accounted for the highest scientific output, with Erasmus University Rotterdam standing out as the leading institution. Among the most productive authors were Leebeek, Cnossen, and Eikenboom, while O’Donnell and Peyvandi showed the highest relative impact and h-index, respectively. The journals hemophilia and blood ranked as the main means of dissemination, with high normalized impact and citation metrics. The subcategory hematology was the most published. Three co-authorship clusters were identified: United States-Canada–Ireland, United Kingdom, and Netherlands–France–Italy. CONCLUSIONS: Research on VWD is led by the United States and, notably, by the Netherlands, which differs from other hematological fields where China often occupies dominant positions. The centrality of Q1 journals and multinodal networks reveal a dynamic field with potential for expansion into emerging countries. These findings can guide future collaborative agendas and optimize the visibility of research.